Tubulin Polymerization Inhibitor II

Biochem/physiol Actions

Reversible: no

Product does not compete with ATP.

Target IC₅₀: 4.5 µM in inhibiting polymerization of purified porcine brain tubulin

Primary TargetPurified porcine brain tubulin

Cell permeable: yes

General description

A cell-permeable, SU5416- (Cat. Nos. 676487 and 676498) derived combretastatin A-4 (Cat. No. 234200) analog that acts as an effective anti-microtubule agent (IC₅₀ = 4.5 µM in inhibiting polymerization of purified porcine brain tubulin) and displays extremely potent anti-proliferative activity towards various cancer cell lines (GI₅₀﹤10 nM for 46 lines among a 53 NCI panel tested).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Pandit, B., et al. 2006. Bioorg. Med. Chem.14, 6492.Li, P.K., et al. 2005. Bioorg. Med. Chem. Lett.15, 5382.

Packaging

Packaged under inert gas

5 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Harmful (C)